Suspect poisoning? US: ASPCA Poison Control (888) 426-4435 · UK: 01202 509 000 · Severe symptoms → nearest emergency vet now.

Tramadol & Opioid Painkillers

Opioid painkillers cause sedation, a dangerously slow heart rate and, at higher doses, breathing failure — and cats are especially sensitive.

Last reviewed: 2026-09-05 · Reference ranges: ASPCA, Pet Poison Helpline & Merck Veterinary Manual

Treat this as a potential emergency — not a "wait and see" situation.
Contact your vet before symptoms even appear.

US: ASPCA Animal Poison Control (888) 426-4435 · Pet Poison Helpline (855) 764-7661

UK: Veterinary Poisons Information Service 01202 509 000

Why is it dangerous to pets?

Tramadol, codeine, hydrocodone, oxycodone and morphine all depress the central nervous system and breathing drive. Pets become profoundly sedated, their pupils shrink to pinpoints, and breathing can slow to a stop.

Tramadol lowers the seizure threshold, so a poisoned pet can also fit. Human combination tablets often add acetaminophen or ibuprofen.

Why speed matters

Delaying care significantly worsens outcomes. Some signs appear hours or days later, so "looks fine right now" is not a reason to wait.

Symptoms of opioids poisoning

  • Extreme drowsiness, difficulty rousing
  • Pinpoint pupils
  • Very slow, shallow breathing
  • Wobbliness, slow heart rate, low body temperature
  • Tremors, seizures, coma (tramadol and severe overdose)

What to do right now

  1. This is an emergency — go now. Opioid overdose can stop breathing.
  2. Keep the airway clear and never leave the pet alone.
  3. Bring the medication; the vet may use naloxone, an antidote that reverses many opioids.
  4. Do not give food, drink or other medicines.
If your pet shows any of the signs above, go to the nearest emergency vet now and call ahead.

Sources & further reading

  • ASPCA Animal Poison Control — pet poison database & dosage references
  • Pet Poison Helpline — toxicology triage guidelines
  • Merck Veterinary Manual — toxicology monographs
  • Vets Now (UK) — emergency toxicosis guidance