Why is this dangerous?
Tramadol, codeine, hydrocodone, oxycodone and morphine all depress the central nervous system and breathing drive. Pets become profoundly sedated, their pupils shrink to pinpoints, and breathing can slow to a stop.
Tramadol lowers the seizure threshold, so a poisoned pet can also fit. Human combination tablets often add acetaminophen or ibuprofen.
Why speed matters
Delaying care significantly worsens outcomes. Some signs appear hours or days later, so "looks fine right now" is not a reason to wait.
Signs to watch for
- Extreme drowsiness, difficulty rousing
- Pinpoint pupils
- Very slow, shallow breathing
- Wobbliness, slow heart rate, low body temperature
- Tremors, seizures, coma (tramadol and severe overdose)
What to do right now
- This is an emergency — go now. Opioid overdose can stop breathing.
- Keep the airway clear and never leave the pet alone.
- Bring the medication; the vet may use naloxone, an antidote that reverses many opioids.
- Do not give food, drink or other medicines.
If your pet shows any of the signs above, go to the nearest emergency vet now and call ahead.
The step-by-step response, from the first minute to the vet visit, is in our Tramadol & Opioid Painkillers emergency guide.