Suspect poisoning? US: ASPCA Poison Control (888) 426-4435 · UK: 01202 509 000 · Severe symptoms → nearest emergency vet now.

Melatonin Supplement Overdose in Dogs and Cats

Overdose of melatonin, commonly used for sleep or anxiety, can cause drowsiness, digestive upset, and increased heart rate in pets.

Last reviewed: 2026-09-05 · Reference ranges: ASPCA, Pet Poison Helpline & Merck Veterinary Manual

Treat this as a potential emergency — not a "wait and see" situation.
Contact your vet before symptoms even appear.

US: ASPCA Animal Poison Control (888) 426-4435 · Pet Poison Helpline (855) 764-7661

UK: Veterinary Poisons Information Service 01202 509 000

How melatonin affects pets

Melatonin mimics the body's natural sleep hormone, slowing brain activity.

Pets metabolize it differently than humans, leading to prolonged effects.

Combination products with xylitol are especially dangerous.

Why speed matters

Delaying care significantly worsens outcomes. Some signs appear hours or days later, so "looks fine right now" is not a reason to wait.

Symptoms of melatonin-supplements poisoning

  • Drowsiness and lethargy starting within 30 minutes to 2 hours.
  • Vomiting and diarrhoea if the product contains other additives.
  • Increased heart rate or palpitations noted as restlessness.
  • Weakness or stumbling when walking.
  • In severe cases, coma or seizures from combined ingredients.

What to do right now

  1. Call your vet or poison line immediately; have the supplement bottle ready.
  2. Check if the product contains xylitol – if yes, this is an emergency.
  3. Do not induce vomiting unless instructed by a professional.
  4. Monitor breathing and heart rate for signs of distress.
  5. Keep all supplements out of reach, especially gummy forms that look like candy.
If your pet shows any of the signs above, go to the nearest emergency vet now and call ahead.

Sources & further reading

  • ASPCA Animal Poison Control — pet poison database & dosage references
  • Pet Poison Helpline — toxicology triage guidelines
  • Merck Veterinary Manual — toxicology monographs
  • Vets Now (UK) — emergency toxicosis guidance

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Frequently asked questions

Is Melatonin Supplement Overdose in Dogs and Cats poisonous to a dog or cat?

Melatonin mimics the body's natural sleep hormone, slowing brain activity.

What are the symptoms of melatonin-supplements poisoning?

Drowsiness and lethargy starting within 30 minutes to 2 hours.; Vomiting and diarrhoea if the product contains other additives.; Increased heart rate or palpitations noted as restlessness.; Weakness or stumbling when walking.

What should I do if my pet ate Melatonin Supplement Overdose in Dogs and Cats?

Call your vet or poison line immediately; have the supplement bottle ready. Check if the product contains xylitol – if yes, this is an emergency. Do not induce vomiting unless instructed by a professional.

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