Suspect poisoning? US: ASPCA Poison Control (888) 426-4435 · UK: 01202 509 000 · Severe symptoms → nearest emergency vet now.

My 5 kg cat has been accidentally getting a half-tablet of levothyroxine in her food every day for two weeks — what will happen?

Cats · Emergency guide

Last reviewed: 2026-09-05 · Reference ranges: ASPCA, Pet Poison Helpline & Merck Veterinary Manual

Short answer

Yes, this is a serious overdose. Levothyroxine is a thyroid hormone, and giving it daily to a cat that doesn't need it will cause acute hyperthyroidism. Over days, her heart rate and body temperature will climb, and she'll become agitated, restless, and may start trembling. Many owners miss that a chewed bottle cap lets tablets fall into the food bowl over and over. Call your vet or the ASPCA poison line at 888-426-4435 immediately — stop the medication and bring the bottle so they can see the exact strength.

Two weeks of accidental dosing is an eternity for a cat

Your 5 kg cat’s system has been flooded with thyroid hormone daily, essentially forcing her body into overdrive. Unlike a single overdose, this prolonged exposure means her organs have been straining nonstop—her heart muscle may already be thickening from the effort.

Cats are especially sensitive to thyroid changes, which is why hyperthyroidism is common in older felines. But artificially inducing it in a healthy cat through medication creates chaos their body can’t regulate.

Why half-tablets add up catastrophically

Even a quarter of a human thyroid pill exceeds a cat’s safe threshold. Over fourteen days, this isn’t just an overdose—it’s a systemic rewiring of her metabolism. You might notice weight loss despite increased appetite, or litter box changes from the kidneys working overtime.

The trembling and restlessness owners often dismiss as ‘quirky behavior’ are actually neurological distress signals. Without intervention, this progresses to labored breathing and possible heart failure.

The deceptive calm before the storm

Cats hide illness well, so visible symptoms mean the damage is advanced. That ‘energetic’ cat zooming around at 3 AM? That’s not playfulness—it’s mania from excess hormone. The real crisis comes when she suddenly crashes from exhaustion.

Bloodwork will likely show dangerously elevated T4 levels, but more critically, her potassium and liver values may be skewed from sustained stress. This requires careful rebalancing—stopping the pills abruptly isn’t enough.

Recovery isn’t just stopping the pills

The vet will taper treatment carefully because sudden hormone withdrawal shocks the system. Expect subcutaneous fluids to flush the toxin and medications to protect the heart during recovery.

Monitor sleep patterns closely—true improvement shows as normalized rest cycles, not just reduced hyperactivity. Full recovery takes weeks, with follow-up blood tests to confirm her thyroid self-regulates again.

The step-by-step response, from the first minute to the vet visit, is in our Thyroid Medicines (Levothyroxine) emergency guide.

Open the full emergency guide: Thyroid Medicines (Levothyroxine) →