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Is metformin safe for a 22 kg pregnant dog at eight weeks gestation, and what risks does it pose to the developing puppies?

Dogs · Emergency guide

Last reviewed: 2026-09-05 · Reference ranges: ASPCA, Pet Poison Helpline & Merck Veterinary Manual

Short answer

Metformin crosses the placenta and can lower blood glucose in both the mother and her developing puppies, which is dangerous because a pregnant dog's energy demands are already high. Hypoglycaemia in the mother can trigger weakness, wobbliness, and seizures — and in severe cases, collapse. The puppies are at particular risk because their brains depend on a steady glucose supply throughout gestation. Do not administer metformin during pregnancy without explicit veterinary guidance, and if your dog has already taken a dose, call your vet immediately to discuss monitoring and next steps.

Why is this dangerous?

Insulin injected or chewed from a pen, and oral drugs such as metformin and glipizide, all lower blood glucose. A pet that has taken too much becomes hypoglycaemic — the brain runs out of fuel within 30 minutes to a few hours.

Pets already on insulin are at extra risk: a double dose or a chewed insulin pen is a common household accident.

Why speed matters

Delaying care significantly worsens outcomes. Some signs appear hours or days later, so "looks fine right now" is not a reason to wait.

Signs to watch for

  • Weakness, wobbliness, staggering
  • Confusion, staring, unusual behaviour
  • Tremors, seizures
  • Collapse, coma
  • Vomiting and drooling before neurological signs

What to do right now

  1. If the pet is awake and able to swallow, offer a small amount of honey, syrup or food and call the vet at once.
  2. Do not put anything in the mouth of a drowsy or seizing pet — it can be inhaled.
  3. Go to the vet; blood glucose needs to be measured and monitored for hours.
  4. Bring the pen or bottle so the dose taken can be estimated.
If your pet shows any of the signs above, go to the nearest emergency vet now and call ahead.

The step-by-step response, from the first minute to the vet visit, is in our Diabetes Medicines (Metformin, Insulin) emergency guide.

Open the full emergency guide: Diabetes Medicines (Metformin, Insulin) →